CYSTINE METABOLISM
نویسندگان
چکیده
منابع مشابه
Cystine Deficiency and Cholesterol Metabolism in Primates
• A deficiency of sulfur amino acids impairs sterol metabolism in several species.' The present work with primate species was directed at an explanation of this phenomenon. The role of dietary cholesterol in the regulation of blood cholesterol has been best documented for the rat* In that rodent, synthesis of cholesterol is reduced by the administration of dietary cholesterol. Gould et al. show...
متن کاملDisturbances of cystine metabolism in liver disease.
The urinary excretion of cystine, as determined on the polarograph, varies, in normal adults, between 40 and 80 mg. daily (1). It may be increased either as a result of a low renal threshold for cystine or a raised plasma cystine concentration. Cystinuria due to a low renal threshold occurs in 'classical cystinuria,' the Fanconi syndrome and hepatolenticular degeneration (2). In such conditions...
متن کاملThe Metabolism of Cystine and Methionine
Preformed protein, or its hydrolysis products, is one of the inevit.able needs of the more complexly organized animal body. The particular metabolic requirement for each individual amino acid yielded by protein is, therefore, a matter of outstanding importance. Although it has been clearly recognized for some 20 years that amino acids might well differ in their degrees of nutritional significan...
متن کاملCystine Stones
Cystine stones occur in subjects carrying two autosomal mutant alleles resulting in excessive excretion of cystine, ornithine, arginine and lysine – hence the condition cystinuria. About 1:15–25 000 NSW neonates have been found to have cystinuria, with a gene frequency in Australia calculated to be about 1:4000 individuals. Since these studies were published, the mutant alleles have been identi...
متن کاملCystine nephrolithiasis
Our understanding of the molecular basis of cystinuria has deepened as the result of the causative genes, SLC3A1 and SLC7A9, being identified. The proteins coded for by these genes form a heterodimer responsible for reabsorption of filtered cystine in the proximal tubule. Failure of this transport system to be targeted to the apical membrane, as in the case of SLC3A1 mutations, or failure of th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1937
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)74462-1